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House's begrudging fulfillment of his mandatory walk-in clinic duty is a recurring subplot on the show. During clinic duty, House confounds patients with an eccentric bedside manner and unorthodox treatments, but impresses them with rapid and accurate diagnoses after seemingly not paying attention. Realizations made during some of the simple problems House faces in the clinic often help him solve the main case.

Episodes frequently feature the practice of entering a patient's house with or without the owner's permission in order to search for clues that might suggest a certain pathology. The creator, David Shore, originally intended for the show to be a CSI-type show where the "germs were the suspects,"[4] but has since shifted much of the focus to the characters rather than concentrating solely on the environment.

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