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The team arrives at diagnoses using the Socratic method and differential diagnosis, with House guiding the deliberations. House often discounts the information and opinions from his underlings, pointing out that their contributions have missed various relevant factors. The patient is usually misdiagnosed over the course of each episode and treated with medications appropriate to the misdiagnoses. This usually causes further complications in the patient, but in turn helps lead House and his team to the correct diagnosis by using the new symptoms.

Often the ailment cannot be easily deduced because the patient has lied about symptoms and circumstances. House frequently mutters, "Everybody lies," or proclaims during the team's deliberations: "The patient is lying," or "The symptoms never lie." Even when not stated explicitly, this assumption guides House's decisions and diagnoses.

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